β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-, 2-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
ForsythosideH
CAS: 1178974-85-0
Molecular Formula: C29H36O15
β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-, 2-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate] - Names and Identifiers
β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-, 2-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate] - Physico-chemical Properties
| Molecular Formula | C29H36O15 |
| Molar Mass | 624.59 |
| Density | 1.60±0.1 g/cm3(Predicted) |
| Boling Point | 911.9±65.0 °C(Predicted) |
| Solubility | Soluble in methanol |
| Appearance | Powder |
| pKa | 9.31±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-, 2-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate] - Reference
| Reference Show more | 1. Xu Lin, Song Jian, Feng Yu, Zhang Huimin, Wang Ping. Study on orthogonal experiment of ultrafine constant temperature extraction of Yinqiao powder [J]. Chinese Journal of Shizhen National Medicine, 2020,31(09):2127-2130. |
β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-, 2-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate] - Reference Information
| overview | forsythioside h is an effective ingredient extracted from FructusForsythiae, a plant of the genus Forsythia of Oleaceae. |
| use | in recent years, with the in-depth research on the effective components of forsythia suspensa, it has been found that forsythin has no antibacterial activity, and forsythine is the one that exerts antibacterial activity. Forsythioside H is a kind of forsythioside. |
| preparation | (1) the total extract of the traditional Chinese medicine composition is separated by AB-8 macroporous resin, eluted with water, 10% ethanol and 30% ethanol in sequence, collected 30% ethanol eluent, recovered solvent, and obtained 30% ethanol extract;(2) The 30% ethanol extract obtained in step (1) is added with reversed-phase silica gel ODS-AQ-HG(S-50μm) to mix the sample. After the mixed sample ODS is naturally dried, the mixed sample ODS is added into the sample column, and the liquid phase is prepared at upper and medium pressure for separation (the packing of the separation column is ODS-AQ-HG(S-50μm)), and 10% methanol is used in turn to obtain 5 streams according to the elution sequence, they are numbered 10%-1, 10%-2, 10%-3, 10%-4, 10%-5;20% methanol elution, 6 streams are obtained according to the elution sequence, numbered 20%-1, 20%-2, 20%-3, 20%-4, 20%-5 and 20%-6, respectively, to collect eluent and recover solvent, the number is 10%-1, 10%-2, 10%-3, 10%-4, 10%-5 eluting dry paste and 20%-1, 20%-2, 20%-3, 20%-4, 20%-5 and 20%-6 eluting dry paste;(3) The number obtained in step (2) is 10%-1 eluting dry paste, dissolved with 30% methanol, the dissolved liquid was preliminarily separated by high performance liquid chromatography through 0.45 μm microporous filter membrane. The mobile phase was methanol-water 22:78, the flow rate was 1ml/min, and the detection wavelength was 210nm. The chromatographic peaks with retention time of 3-9min, 9-11min, 19-22min, 22-26min, 26-30min, 37-41min, and 44-48min were collected respectively, and the solvent was recovered under reduced pressure and separated respectively. The 18 compounds are forsythin A(1), forsythin I(2), forsythin H(3), Lugrandoside(4), Isolugrandoside(5), FerruginosideA(6), LianqiaoxinganC(7), CalceolariosideC(8), forsythin E(9), FerruginosideB(10), D-amygdalin (11), L-amygdalin (12), Sambunigrin(13), Cornoside(14), 5-dienone(15), Liriodendrin(16), liquiritin-7-O-β-D-glucoside (17), 3, 4-dihydroxybenzaldehyde (18). |
| biological activity | Forsythoside H is a coffee-based phenylethanol glycoside (CPG) isolated from Forsythia suspense (Thunb.) Vahl, which may have anti-inflammatory effects. |
Last Update：2024-04-10 22:29:15
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Mobile: 18021002903
QQ: 3008007409
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